过敏性接触性皮炎中的分子识别。双功能半抗原的概念。
Molecular recognition in allergic contact dermatitis. The concept of double-headed haptens.
作者信息
Benezra C
机构信息
Laboratoire de Dermatochimie, Université Louis Pasteur, Strasbourg, France.
出版信息
Dermatol Clin. 1990 Jan;8(1):13-6.
PMID:2302850
Abstract
The sensitizing capacity of double-headed haptens containing the pyrocatechol and alpha-methylene-gamma-butyrolactone groups reveals that only the pyrocatechol end is recognized as a sensitizer. Prior sensitization to the double-headed hapten provides protection against (induces immune tolerance to) further sensitization to the lactone hapten.
摘要
含有邻苯二酚和α-亚甲基-γ-丁内酯基团的双头半抗原的致敏能力表明，只有邻苯二酚末端被识别为致敏剂。预先对半抗原致敏可防止（诱导免疫耐受）对内酯半抗原的进一步致敏。
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