Skinner C S, Kilgore W W
J Toxicol Environ Health. 1982 Mar;9(3):483-90. doi: 10.1080/15287398209530179.
Percutaneous penetration of [14C]parathion in mouse skin of nose, hind foot, scrotum, and tail was measured by recovery of excreted radioactivity relative to an intravenous dose. Oral ingestion was prevented by use of face muzzles and polyethylene rings at application sites. Penetration per unit area was in the following order (iv = 1.0): nose (0.8), scrotum (0.4), foot (0.3), and tail (0.3). Because of their greater surface area, tail and foot regions would contribute most to absorption in uniform ventral exposure. Daily recovery curves indicate apparent first-order kinetics of elimination.
通过相对于静脉注射剂量回收排泄的放射性，测量了[14C]对硫磷在小鼠鼻子、后足、阴囊和尾巴皮肤中的经皮渗透。在应用部位使用面罩和聚乙烯环来防止经口摄入。单位面积的渗透率顺序如下（静脉注射=1.0）：鼻子（0.8）、阴囊（0.4）、足部（0.3）和尾巴（0.3）。由于尾巴和足部区域的表面积较大，在均匀的腹部暴露中它们对吸收的贡献最大。每日回收曲线表明消除呈现明显的一级动力学。
