Wada O, Miyahara A, Manabe S, Matsui H, Ono T
J Toxicol Environ Health. 1982 Mar;9(3):509-13. doi: 10.1080/15287398209530182.
Acute administration of sc doses of Cd (1mg/kg . d, 3 or 6 d) to male golden hamsters resulted in a remarkable dose-dependent increase of Zn in the liver and kidney. In contrast, Zn contents in the heart and testes showed a significant dose-dependent decrease. No change was found in Zn contents of the bone. The correlation coefficients between contents of Cd and Zn in the liver and kidney were much higher in metallothionein fractions than in the corresponding whole organs. These results suggest that Cd induces the synthesis of metallothionein in the liver and kidney, leading to simultaneous accumulation of Cd and Zn in the organs; this in turn decreases the Zn contents in other organs, where weak or no induction of metallothionein synthesis takes place. Therefore Cd might induce Zn deficiency in humans or animals whose pool size and intake of Zn are marginal.
给雄性金黄地鼠皮下注射镉（1毫克/千克·天，3天或6天）后，肝脏和肾脏中的锌含量显著增加，且呈剂量依赖性。相反，心脏和睾丸中的锌含量则呈显著的剂量依赖性下降。骨骼中的锌含量未发现变化。金属硫蛋白组分中肝脏和肾脏中镉和锌含量之间的相关系数比相应的整个器官中的相关系数高得多。这些结果表明，镉诱导肝脏和肾脏中金属硫蛋白的合成，导致镉和锌在这些器官中同时积累；这反过来又降低了其他器官中的锌含量，在这些器官中金属硫蛋白合成的诱导较弱或没有发生。因此，镉可能会在锌储备量和摄入量处于边缘水平的人类或动物中诱发锌缺乏。
