Yamamoto T, Egashira T, Yoshida T, Kuroiwa Y
J Toxicol Sci. 1982 Feb;7(1):35-41. doi: 10.2131/jts.7.35.
The effects of fenitrothion and methylparathion on the activities of cholinesterase and hepatic microsomal monooxygenases were investigated and compared following a single or repeated oral administration of an equimolar and low dose of the insecticides. The activities of cholinesterase in brain and plasma were inhibited equally by the repetitive administration of both insecticides. Aminopyrine N-demethylase activity and cyt.P-450 content were not affected under the same experimental conditions. However, methylparathion, when given repeatedly, inhibited the dearylation and desulfuration of it own. The results may indicate that low dose continuous exposure to methylparathion could cause the depression of its own metabolism in rat.
在单次或重复口服等摩尔低剂量杀螟硫磷和甲基对硫磷后，研究并比较了它们对胆碱酯酶和肝微粒体单加氧酶活性的影响。两种杀虫剂重复给药时，脑和血浆中的胆碱酯酶活性受到同等程度的抑制。在相同实验条件下，氨基比林N - 脱甲基酶活性和细胞色素P - 450含量未受影响。然而，甲基对硫磷重复给药时，会抑制其自身的脱芳基作用和脱硫作用。结果可能表明，低剂量持续接触甲基对硫磷会导致大鼠体内其自身代谢的抑制。
