氨基糖苷类药物用于治疗与急性白血病相关的传染病。庆大霉素静脉滴注给药（作者译）
[Aminoglycoside for the infectious disease associated with acute leukemia. Gentamicin intravenous drip administration (author's transl)].
作者信息
Uchida T, Matsuda S, Kariyone S
出版信息
Jpn J Antibiot. 1982 Mar;35(3):731-8.
In 29 patients of infection diseases associated with acute leukemia, 60 to 160 mg/day of gentamicin was injected intravenously drip infusion. The results showed that 69.0% of the cases were clinically effective (excellent+good+fair), and 31% ineffective. Abnormal GOT and GPT level was temporarily noted in 2 cases and audiovestibular dysfunction in 1 case, which improved after the discontinuation of the injection. Safety of the intravenous drip administration of gentamicin was discussed. The patients with acute leukemia might easily have opportunistic infection by Gram negative rods and it is more advantageous to administer intravenously drip infusion than intramuscularly because of hemorrhagic tendency.
在29例与急性白血病相关的感染性疾病患者中，静脉滴注庆大霉素，剂量为每日60至160毫克。结果显示，69.0%的病例临床有效（优+良+中），31%无效。2例患者出现谷草转氨酶（GOT）和谷丙转氨酶（GPT）水平暂时异常，1例出现听觉前庭功能障碍，停药后均有所改善。讨论了庆大霉素静脉滴注给药的安全性。急性白血病患者容易发生革兰氏阴性杆菌的机会性感染，由于有出血倾向，静脉滴注给药比肌肉注射更具优势。
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