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阿替洛尔与普萘洛尔对自发性高血压大鼠、去氧皮质酮/生理盐水诱导高血压大鼠及肾性高血压大鼠降压作用的比较。

A comparison of antihypertensive effects of atenolol and propranolol in the spontaneously hypertensive, DOCA/saline hypertensive and renal hypertensive rats.

作者信息

Takeda K, Nakagawa Y, Chin W P, Imai S

出版信息

Jpn J Pharmacol. 1982 Apr;32(2):283-9. doi: 10.1254/jjp.32.283.

DOI:10.1254/jjp.32.283
PMID:7098145
Abstract

Antihypertensive effects of a long-term oral regimen of atenolol were studied in SHR, DOCA/saline hypertensive and renal hypertensive rats (one kidney, one clip) in comparison with the effects of propranolol. Both the beta-blockers prevented the development of hypertension in SHR but did not affect that in DOCA/saline and renal hypertensive rats. Both of the beta-blockers produced no acute hypotensive effects on the established DOCA/saline and renal hypertension of the rat, although they produced a decrease in the heart rate.

摘要

在自发性高血压大鼠（SHR）、去氧皮质酮/盐水诱导的高血压大鼠和肾性高血压大鼠（单肾单夹）中，研究了阿替洛尔长期口服方案的降压作用，并与普萘洛尔的作用进行比较。两种β受体阻滞剂均可预防SHR高血压的发展，但对去氧皮质酮/盐水诱导的高血压大鼠和肾性高血压大鼠无效。两种β受体阻滞剂对大鼠已形成的去氧皮质酮/盐水诱导的高血压和肾性高血压均无急性降压作用，尽管它们可使心率降低。

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引用本文的文献

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Enhancement of arterial relaxation by long-term atenolol treatment in spontaneously hypertensive rats.长期阿替洛尔治疗对自发性高血压大鼠动脉舒张功能的增强作用。
Br J Pharmacol. 1994 Jul;112(3):925-33. doi: 10.1111/j.1476-5381.1994.tb13169.x.