Imaizumi Y, Katoh M, Sugimoto T, Kasai T
Jpn J Pharmacol. 1982 Apr;32(2):369-75. doi: 10.1254/jjp.32.369.
The effect of malotilate (diisopropyl 1,3-dithiol-2-ylidenemalonate) on the protein synthesis in rat liver was studied in vivo and in vitro. Oral administration of malotilate to rats caused an increase in the protein and RNA contents of the liver and lef to an acceleration of 14C-leucine incorporation into microsomal and cytosol proteins. In a cell-free system, the protein synthesis was enhanced by treatment with malotilate, and an unknown factor(s) which participates in the protein synthesis was found in the cytosol fraction prepared from malotilate treated livers. These results suggest that malotilate is a new type of inducer for protein synthesis. On the basis of the observations obtained in the present study, a hypothesis can be formulated that malotilate enhances liver protein synthesis by accelerating RNA synthesis and/or increasing the transport of RNA from nuclei to cytosol in rat liver.
研究了马洛替酯（1,3 - 二硫杂环戊烯 - 2 - 亚基丙二酸二异丙酯）对大鼠肝脏蛋白质合成的体内和体外作用。给大鼠口服马洛替酯会导致肝脏蛋白质和RNA含量增加，并使14C - 亮氨酸掺入微粒体和胞质溶胶蛋白质的过程加速。在无细胞系统中，用马洛替酯处理可增强蛋白质合成，并且在从经马洛替酯处理的肝脏制备的胞质溶胶组分中发现了一种参与蛋白质合成的未知因子。这些结果表明马洛替酯是一种新型的蛋白质合成诱导剂。基于本研究获得的观察结果，可以提出一个假设，即马洛替酯通过加速RNA合成和/或增加大鼠肝脏中RNA从细胞核向胞质溶胶的转运来增强肝脏蛋白质合成。
