Weidauer H
Laryngol Rhinol Otol (Stuttg). 1982 May;61(5):242-5.
The therapeutic results of squamous cell carcinoma of the external auditory meatus and the middle ear by operation and radiation are subject to an unfavourable prognosis: the 5 years' survival time represents 25% of the external auditory meatus and 15% of the middle-ear carcinoma cases. In comparison to the improved median survival time of carcinoma of the oral cavity and oropharynx by means of a combination of primary antineoplastic chemotherapy (Heidelberg Scheme), surgery and radiation, an improved median survival time should be expected even in keratinizing squamous cell carcinoma of the external auditory meatus and the middle ear. The stages of remission of a carcinoma of the external auditory meatus and the middle-ear carcinoma are demonstrated at different times of the antineoplastic treatment (Heidelberg Scheme). The field of indication is outlined. Primary antineoplastic chemotherapy extends the possibilities of intended curative therapy. As a palliative therapy it is an alternative to petrosectomy which has a high mortality in very advanced carcinoma of the middle ear.
5年生存率在外耳道癌病例中为25%，在中耳癌病例中为15%。与通过原发性抗肿瘤化疗（海德堡方案）、手术和放疗相结合使口腔和口咽癌中位生存时间得到改善相比，即使是外耳道和中耳的角化鳞状细胞癌，其中位生存时间也有望得到改善。外耳道癌和中耳癌在抗肿瘤治疗（海德堡方案）的不同时间显示出缓解阶段。明确了适应证范围。原发性抗肿瘤化疗扩展了预期根治性治疗的可能性。作为一种姑息治疗，它是岩骨切除术的替代方法，岩骨切除术在中耳非常晚期的癌症中死亡率很高。
