Waldemar E, Sørensen T, Bretlau P, Hansen H S
Ore-naese-halsafdelingen og onkologisk afdeling, Rigshospitalet, København.
Ugeskr Laeger. 1995 Apr 10;157(15):2139-42.
Thirty-seven patients with malignant tumours in the ear treated at Rigshospitalet, Copenhagen in the period 1.6.1983-1.6.1993 were retrospectively reviewed. There were 20 males and 17 females. The average age was 67 years. Twenty-four patients had tumours involving the middle ear and 13 patients had tumours located only in the external auditory canal. Eighty-four percent had squamous cell carcinoma. In 61% of the patients with squamous cell carcinoma, chronic infection of the ear preceded the malignant process. Overall control of disease for the 37 patients was 49%. The total actuarial crude survival was 33%. For the nine patients who had squamous cell carcinoma located only in the external auditory canal, the control of disease was 89%. Twenty-two patients had squamous cell carcinoma involving the middle ear. Most of these patients underwent radical mastoidectomy and step-wise removal of gross tumour followed by radiotherapy. Six had radiotherapy alone. The control of disease in this group was 32%. It is concluded that tumours involving only the external auditory canal have a good prognosis. If the tumour involves the middle ear, the prognosis falls dramatically.
对1983年6月1日至1993年6月1日期间在哥本哈根里格霍斯医院接受治疗的37例耳部恶性肿瘤患者进行了回顾性研究。其中男性20例,女性17例。平均年龄为67岁。24例患者的肿瘤累及中耳,13例患者的肿瘤仅位于外耳道。84%为鳞状细胞癌。在61%的鳞状细胞癌患者中,耳部慢性感染先于恶性病变过程。37例患者的疾病总体控制率为49%。总精算粗生存率为33%。对于9例仅位于外耳道的鳞状细胞癌患者,疾病控制率为89%。22例患者的鳞状细胞癌累及中耳。这些患者中的大多数接受了根治性乳突切除术和逐步切除肉眼可见肿瘤,随后进行放疗。6例仅接受了放疗。该组的疾病控制率为32%。结论是,仅累及外耳道的肿瘤预后良好。如果肿瘤累及中耳,预后则会急剧下降。