Kawasaki K, Matsushita A
Life Sci. 1982 May 10;30(19):1625-9. doi: 10.1016/0024-3205(82)90494-5.
Intraventricular administration of muscimol (25-100 ng) and intravenously applied aminooxyacetic acid (2.5-10 mg/kg) depressed the crossed extensor reflex response in a dose-dependent manner. The inhibitory effects of both drugs were clearly antagonized by a subconvulsive dose of bicuculline. A very small dose of bicuculline (10-40 microgram/kg, i.v.) produced a dose-related enhancement of the crossed extensor reflex response without any sign of convulsion. These results suggest that the crossed extensor reflex response is very sensitive to GABAergic drugs and central GABAergic mechanisms play a role in the modulation of the crossed extensor reflex response.
脑室内注射蝇蕈醇（25 - 100纳克）和静脉注射氨氧乙酸（2.5 - 10毫克/千克）以剂量依赖性方式抑制交叉伸肌反射反应。两种药物的抑制作用均被亚惊厥剂量的荷包牡丹碱明显拮抗。非常小剂量的荷包牡丹碱（10 - 40微克/千克，静脉注射）产生与剂量相关的交叉伸肌反射反应增强，且无任何惊厥迹象。这些结果表明，交叉伸肌反射反应对GABA能药物非常敏感，并且中枢GABA能机制在交叉伸肌反射反应的调节中起作用。
