中枢性尿崩症患者中去氨基-8-D-精氨酸加压素（DDAVP）的药代动力学
Pharmacokinetics of 1-desamino-8-D-arginine vasopressin (DDAVP) in patients with central diabetes insipidus.
作者信息
Pullan P T, Burger H G, Johnston C I
出版信息
Clin Endocrinol (Oxf). 1978 Sep;9(3):273-8. doi: 10.1111/j.1365-2265.1978.tb02210.x.
Abstract
The pharmacokinetic parameters and biological duration of action of DDAVP were measured in five patients with central diabetes insipidus of differing severity. Plasma half-life correlated significantly with the duration of action (r = 0.89, P less than 0.05), 0ut there was no correlation between the severity of diabetes insipidus and either plasma half-life or duration of action of DDAVP.
摘要
在五名不同严重程度的中枢性尿崩症患者中测量了去氨加压素的药代动力学参数和生物学作用持续时间。血浆半衰期与作用持续时间显著相关（r = 0.89，P < 0.05），但尿崩症的严重程度与去氨加压素的血浆半衰期或作用持续时间之间均无相关性。
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