Ohtani I, Ohtsuki K, Aikawa T, Omata T, Ouchi J, Saito T
ORL J Otorhinolaryngol Relat Spec. 1982;44(3):156-69. doi: 10.1159/000275589.
The ototoxicity and nephrotoxicity of aminoglycoside antibiotics (dibekacin, gentamicin and kanamycin) administered to rabbits by rapid intravenous or intramuscular injections were histopathologically compared. Comparative evaluations between the two routes were further made concerning the levels of the antibiotics in serum and in perilymph. The results revealed that, although the peak serum level after a rapid intravenous injection was significantly higher than that observed after an intramuscular injection, no differences in the transfer into the perilymph, and in inner ear or renal damage were seen between the two different routes. In other words, the results of the present study did not support the conventional idea that the higher the peak blood levels of the aminoglycoside antibiotics, the greater the risk of damage to the inner ear or kidney.
通过快速静脉注射或肌肉注射给予兔子氨基糖苷类抗生素（双去氧卡那霉素、庆大霉素和卡那霉素），对其耳毒性和肾毒性进行了组织病理学比较。还就血清和外淋巴中抗生素的水平，对这两种给药途径进行了比较评估。结果显示，虽然快速静脉注射后的血清峰值水平显著高于肌肉注射后的水平，但在两种不同途径之间，外淋巴中的药物转移以及内耳或肾脏损伤方面未见差异。换句话说，本研究结果不支持传统观点，即氨基糖苷类抗生素的血药峰值水平越高，对内耳或肾脏造成损害的风险就越大。
