Harrap K A
Parasitology. 1982 Apr;84(Pt 4):269-96. doi: 10.1017/s0031182000053671.
A comprehensive account is given of the evolution of registration guidelines and safety testing procedures for microbial insecticidal agents. Particular emphasis is given to the use of viruses for pest control and the various guidelines developed to assess their possible hazards. The likely gains and risks associated with using viruses are discussed. Several meetings have been held in the last 10 years to assess the hazards of virus insecticides. Some of these meetings have produced recommendations, some have developed guidelines for safety testing. These meetings are reviewed. The various guidelines developed for safety testing are critically evaluated and the UK Registration Criteria for Biological Agents used as Pesticides are reproduced in full. Examples of viruses that have been safety tested and registered for use are given and the criteria used are described. Conclusions are drawn on the merits of the guidelines presently available and the likely future development of safety testing schemes is considered.
本文全面介绍了微生物杀虫剂注册指南和安全测试程序的演变。特别强调了病毒在害虫防治中的应用以及为评估其潜在危害而制定的各种指南。讨论了使用病毒可能带来的收益和风险。在过去10年里召开了几次会议来评估病毒杀虫剂的危害。其中一些会议提出了建议，一些会议制定了安全测试指南。本文对这些会议进行了回顾。对为安全测试制定的各种指南进行了严格评估，并全文转载了英国用作农药的生物制剂注册标准。给出了已经通过安全测试并获准使用的病毒实例，并描述了所采用的标准。得出了关于现有指南优点的结论，并考虑了安全测试计划未来可能的发展。
