Ferretti P G, Bia A, Bufalino L, Cavrini P, Cucinotta D
Pharmatherapeutica. 1982;3(2):119-26.
Recent research has demonstrated the major role of oxygen in the maintenance of normal cerebral function in the elderly and considerable importance has been attributed to the action of intra-erythrocytic 2-3 diphosphoglycerate (2-3 DPG) in favouring the availability of oxygen to the tissues. This property is reportedly helped or potentiated by the pharmacological action of some eumetabolic vasoregulator drugs. According to numerous clinical trials, (-)eburnamonine possesses this property. A two-part study was carried out in elderly volunteers: a double-blind randomized trial on 20 patients treated acutely (10 with an infusion of 100 mg (-)eburnamonine vs 10 controls) and a within-patients crossover trial on 10 patients treated chronically by the oral route. The results showed a significant increase in the 2-3 DPG values and a beneficial modification of P50 after (-)eburnamonine, probably dependent both on the dose and mode of administration. The effect of the drug was much more marked but more fleeting after acute administration and less intense but more lasting after chronic administration. The latter mode of treatment is of interest in view of the therapeutic effects on several symptoms of senile chronic cerebral insufficiency.
最近的研究表明，氧气在维持老年人正常脑功能中起主要作用，红细胞内2,3-二磷酸甘油酸（2,3-DPG）促进组织获取氧气的作用也备受关注。据报道，一些正常代谢的血管调节药物的药理作用有助于或增强了这一特性。根据大量临床试验，（-）埃博纳明具有这一特性。对老年志愿者进行了一项分为两部分的研究：对20例急性治疗患者进行双盲随机试验（10例输注100毫克（-）埃博纳明，10例为对照组），对10例口服长期治疗患者进行患者内交叉试验。结果显示，（-）埃博纳明治疗后2,3-DPG值显著升高，P50有有益改变，这可能取决于剂量和给药方式。急性给药后药物效果更明显但更短暂，慢性给药后效果较弱但更持久。鉴于对老年慢性脑供血不足的几种症状有治疗作用，后一种治疗方式很有意义。
