Lacroix P, Linée P, Le Pollès J B
C R Seances Soc Biol Fil. 1978;172(2):330-6.
The influence of 1-éburnamonine (1-E) and vincamine (Vi) on 2,3-disphosphoglycerate (2,3-DPG) blood level was investigated in awake rats when cyanide (KCN) induced hypoxia was present or not. Used alone, KCN, 1-E and Vi (i.p. route) increased 2,3-DPG blood level. Used with KCN, 1-E or Vi produced a very more important increase of 2,3-DPG than that observed when both drugs were used alone. In all cases, the observed increase was attributed to red cells 2,3-DPG since hematocrite, red-cells count and hemoglobin level were unmodified. The results suggest that the KCN induced increase of 2,3-DPG constitutes a response to hypoxia. On the contrary, that of 1-E or Vi seems to be the result of a metabolic stimulation and could explain in part their antihypoxic properties previously described at cerebral level.
研究了在清醒大鼠中，无论有无氰化物（KCN）诱导的缺氧情况时，1-埃博那明（1-E）和长春胺（Vi）对血液中2,3-二磷酸甘油酸（2,3-DPG）水平的影响。单独使用时，KCN、1-E和Vi（腹腔注射途径）会提高血液中2,3-DPG的水平。与KCN联合使用时，1-E或Vi使2,3-DPG水平升高的幅度比单独使用这两种药物时观察到的要大得多。在所有情况下，观察到的升高归因于红细胞中的2,3-DPG，因为血细胞比容、红细胞计数和血红蛋白水平未发生改变。结果表明，KCN诱导的2,3-DPG升高是对缺氧的一种反应。相反，1-E或Vi诱导的升高似乎是代谢刺激的结果，这可以部分解释它们先前在脑水平上描述的抗缺氧特性。
