Pohloudek-Fabini R, Martin E, Gallasch V
Pharmazie. 1982 Mar;37(3):184-7.
The course of the degradation of tropicamide solutions was elucidated. Thus, inter alia, intramolecular elimination of water leads to a compound comparable to apoatropine that the authors designated by atropicamide. Furthermore, methods are described that permit (after thin-layer chromatographic repartition) to detect and to determine quantitatively the active principle in the presence of its degradation products. Tropicamide is stable in aqueous solution; eye-drops prepared from such a solution (Mydrum) are stable for no less than 5 years.
阐明了托吡卡胺溶液的降解过程。因此，除其他外，分子内脱水会生成一种与阿朴阿托品类似的化合物，作者将其命名为去水托品酰胺。此外，还描述了一些方法，这些方法可以（在薄层色谱重新分配后）在其降解产物存在的情况下检测并定量测定活性成分。托吡卡胺在水溶液中稳定；用这种溶液制备的眼药水（Mydrum）至少稳定5年。
