[Stability of cyclodrin hydrochloride. 3: Stability of cyclodrin hydrochloride as a substance and in ophthalmologic solutions. 51: Contributions to problems concerning the use of plastic receptacles for liquid pharmaceuticals].

The authors deal with the stability of cyclodrin hydrochloride. A reference sample of solid cyclodrin hydrochloride stored for four and a half years showed 0.4-0.6% degradation. A storage stability of five years is considered justifiable. In eye-drops the stability of this active agent is determined by the pH value. Unbuffered eye-drops (optimized formula) are considerably more stable than the buffered solutions hitherto used. Unbuffered eye-drops contained in glass bottles as well as in plastic bottles should be stable for 2-3 years.