左旋咪唑对前列腺素E2诱导的豚鼠离体回肠收缩的增强作用。

Enhancement by levamisole of the contractions induced by prostaglandin E2 in the guinea-pig isolated ileum.

作者信息

Capasso F, Mascolo N, Autore G

出版信息

Prostaglandins. 1982 Mar;23(3):427-32. doi: 10.1016/0090-6980(82)90087-9.

Abstract

The effect of levamisole on prostaglandin E2 (PGE2)-evoked contractions was studied on guinea-pig isolated ileum. Addition of levamisole (10 micrograms/ml) to the organ bath produced a pronounced increase in the amplitude of the PGE2-evoked responses. Levamisole (10 micrograms/ml) also sensitized the guinea-pig isolated ileum to 5-hydroxytryptamine and bradykinin, but not to histamine. The effect of the levamisole was not due to stimulation of autonomic ganglia or cholinergic activity since it was unaffected by hexamethonium or atropine, but it was prevented by indomethacin.

摘要

研究了左旋咪唑对豚鼠离体回肠中前列腺素E2（PGE2）诱发收缩的影响。向器官浴槽中加入左旋咪唑（10微克/毫升）可使PGE2诱发反应的幅度显著增加。左旋咪唑（10微克/毫升）还使豚鼠离体回肠对5-羟色胺和缓激肽敏感，但对组胺不敏感。左旋咪唑的作用并非由于刺激自主神经节或胆碱能活性，因为它不受六甲铵或阿托品的影响，但吲哚美辛可阻止其作用。