前列腺素在豚鼠离体回肠对5-羟色胺收缩反应中的可能作用。
A possible role of prostaglandins in guinea-pig isolated ileum contractions to serotonin.
作者信息
Famaey J P, Fontaine J, Seaman I, Reuse J
出版信息
Prostaglandins. 1977 Jul;14(1):119-24. doi: 10.1016/0090-6980(77)90160-5.
PMID:897207
Abstract
Nine non-steroidal antiinflammatory drugs have been tested for their effect on contractions to serotonin of the guinea-pig isolated ileum. They exert a potent inhibition which is totally reversible by washing out the drugs. It is also well reversed by the addition of small amounts of PGE1 to the bath. It is concluded that prostaglandins exert a role in these contractions to serotonin which is probably specific as well as non specific.
摘要
已对九种非甾体抗炎药对豚鼠离体回肠5-羟色胺收缩的影响进行了测试。它们产生强效抑制作用，通过冲洗药物可完全逆转。向浴液中添加少量前列腺素E1也能很好地逆转这种抑制作用。得出的结论是，前列腺素在这些对5-羟色胺的收缩中发挥作用，这可能既有特异性作用也有非特异性作用。
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引用本文的文献
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