Carnevale P, Lallemant M, Molinier M, Mouchet J, Coz J
Rev Epidemiol Sante Publique. 1982;30(1):49-70.
During a longitudinal survey done in the degraded forest area south of Brazzaville (People's Republic of the Congo), it appeared that plasmodic index of preschool children was always lower than 50% in spite of an inoculation rate of about one infected bite per child per night all along the year. The actual incidence rate estimated with Muench model was ĥ = 0,015 while the recovery rate was r = 0,032 (i.e. about three times faster than the usual values admitted since Mac Donald work) for young children (0 to 4 years old). A computer study has shown that an incidence of h1 = 0,0012 was enough for the "infection" of children (Ross model) while an incidence of h2 = 0,0014 would induce a situation of superinfection (Dietz et al. model). Therefore the actual incidence was 10 to 12 times higher than the critical values of the incidence rate. To decrease the malaria transmission at a level lower than the critical values i.e. to obtain a reproduction rate below I the calculations and graphs have shown that anopheline density or human gametocytaemia have to be reduced by about 90% while the survival rate of the vectors must be reduced by about 12%. Therefore it appeared that the determination of the critical levels of every parameters of malaria transmission is a needful stage for a better planification of any malaria control programme.
在刚果人民共和国布拉柴维尔以南退化林区进行的一项纵向调查中发现,尽管全年每个儿童每晚的感染叮咬率约为一次,但学龄前儿童的疟原虫指数始终低于50%。用明希模型估算的实际发病率ĥ = 0.015,而幼儿(0至4岁)的恢复率r = 0.032(即比自麦克唐纳研究以来公认的正常值快约三倍)。一项计算机研究表明,发病率h1 = 0.0012就足以使儿童“感染”(罗斯模型),而发病率h2 = 0.0014会导致重复感染情况(迪茨等人的模型)。因此,实际发病率比发病率的临界值高10至12倍。为了将疟疾传播降低到低于临界值的水平,即获得低于1的繁殖率,计算和图表显示,按蚊密度或人体配子血症必须降低约90%,而病媒的存活率必须降低约12%。因此,确定疟疾传播各参数的临界水平似乎是更好地规划任何疟疾控制计划的必要阶段。