Santidrián S
Rev Esp Fisiol. 1982 Mar;38(1):71-8.
The urinary output of N tau-methylhistidine (3-methylhistidine: 3-Mehis) and total hydroxy proline (OH-pro) were evaluated to assess the effect of a low-protein diet (low-P) or a low-energy diet (low-E), given for 21 days, on the rates of myofibrillar protein and collagen breakdown in mature male rats. As compared to the control rats, the animals fed the deficient diets showed a significant reduction in the rate of growth and plasma insulin. No major changes were found in the weight of several muscles excised from the animals at the end of the experiment. Total OH-pro was significantly reduced in the low-P rats and 3-Mehis was unchanged when results were normalized to either muscle weight or creatinine output. In conclusion, collagen breakdown was found to be very sensitive to protein depletion in the mature rat, but myofibrillar protein breakdown was not notably affected by protein or calorie malnutrition.
评估了N-τ-甲基组氨酸（3-甲基组氨酸：3-Mehis）和总羟脯氨酸（OH-pro）的尿量，以评估给予21天的低蛋白饮食（低P）或低能量饮食（低E）对成熟雄性大鼠肌原纤维蛋白和胶原蛋白分解速率的影响。与对照大鼠相比，喂食缺乏饮食的动物生长速率和血浆胰岛素显著降低。实验结束时，从动物身上切除的几块肌肉的重量没有发现重大变化。当结果以肌肉重量或肌酐产量进行标准化时，低P大鼠的总OH-pro显著降低，而3-Mehis没有变化。总之，发现胶原蛋白分解对成熟大鼠的蛋白质缺乏非常敏感，但肌原纤维蛋白分解并未受到蛋白质或热量营养不良的显著影响。
