Joubert P, Lowings A, Sebata B
S Afr Med J. 1982 Aug 14;62(8):247-8.
To assess the potential impact of nifedipine in asthma the effects on histamine- and metacholine-induced contractions in guinea-pig tracheal muscle were studied. Nifedipine is a physiological antagonist of these substances, but also appears to antagonize isoprenaline-induced relaxation. Further studies will be necessary to define the precise implications of these observations.
为评估硝苯地平对哮喘的潜在影响，研究了其对豚鼠气管平滑肌组胺和乙酰甲胆碱诱发收缩的作用。硝苯地平是这些物质的生理性拮抗剂，但似乎也能拮抗异丙肾上腺素诱发的舒张。需要进一步研究来明确这些观察结果的确切意义。
