Higashi A, Ikeda T, Uehara I, Matsuda I
Tohoku J Exp Med. 1982 May;137(1):41-7. doi: 10.1620/tjem.137.41.
Longitudinal studies of zinc and copper contents of breast milk were performed in 65 Japanese mothers during their lactation period until 5 months postpartum. They experienced no problems during pregnancy and at delivery. All women had full term healthy infants. Forty-five were multiparous and 20 primiparous. The highest level of zinc content was found in the colostrum, and subsequently the levels declined (p less than 0.005), as lactation progressed. Copper content was stable during the first month of lactation, and then declined gradually (p less than 0.005). Both mineral levels in breast milk ranged with great variance among the subjects at any stages of lactation. Significantly lower zinc level (p less than 0.01) and higher copper level (p less than 0.005) were found in the serum of lactating women three months postpartum, when compared with non-lactating control women. Factors including lactation history, age of lactating women, serum levels and contents of zinc and copper in the hair did not affect the contents of these trace minerals in the breast milk.
对65名日本母亲在哺乳期直至产后5个月期间母乳中的锌和铜含量进行了纵向研究。她们在孕期和分娩时均未出现问题。所有女性均分娩出足月健康婴儿。其中45名是经产妇，20名是初产妇。初乳中锌含量最高，随后随着哺乳期的推进，含量下降（p<0.005）。哺乳期第一个月铜含量稳定，之后逐渐下降（p<0.005）。在哺乳期的任何阶段，母乳中这两种矿物质的水平在受试者之间差异很大。与非哺乳期对照女性相比，产后3个月哺乳期女性血清中的锌水平显著降低（p<0.01），铜水平显著升高（p<0.005）。包括哺乳史、哺乳期女性年龄、血清水平以及头发中锌和铜的含量等因素，均不影响母乳中这些微量元素的含量。
