Barański B
Arch Toxicol. 1986 Apr;58(4):255-60. doi: 10.1007/BF00297116.
Administration of 60 ppm cadmium (Cd) in drinking water from the 1st to the 20th day of gestation to female rats did not affect the viability, body weight gain, food, and water consumption of offspring. The blood hemoglobin level was reduced in 2-week-old females and males but not in 16-week-old offspring. Hematocrit and serum glucose level were not affected at either age. Cadmium concentration in the intestinal wall was increased in both age groups, with marginal uptake in other organs. A decrease in copper (Cu) concentration was found in the brain of 2-week-old offspring of both sexes and of 16-week-old females. The brain zinc (Zn) concentration was decreased only in 16-week-old animals. The physical and neuromuscular development of offspring before weaning was not impaired by maternal Cd treatment. The alterations in Cu and Zn metabolism were associated with reduced locomotor activity and affected open-field behavior in adult offspring of either sex and with decreased avoidance acquisition in adult female offspring. The results obtained suggest a relationship between the reduced brain Cu and Zn levels and CNS dysfunction in adult offspring of female rats exposed to Cd during gestation.
在妊娠第1天至第20天给雌性大鼠饮用含60 ppm镉（Cd）的水，对其后代的存活率、体重增加、食物和水的消耗量均无影响。2周龄雌性和雄性后代的血液血红蛋白水平降低，但16周龄后代未受影响。两个年龄段的血细胞比容和血清葡萄糖水平均未受影响。两个年龄组的肠壁镉浓度均升高，其他器官的摄取量较少。在2周龄雌雄后代以及16周龄雌性后代的大脑中发现铜（Cu）浓度降低。大脑锌（Zn）浓度仅在16周龄动物中降低。母体镉处理并未损害断奶前后代的身体和神经肌肉发育。铜和锌代谢的改变与成年后代（无论雌雄）的运动活动减少、旷场行为受影响以及成年雌性后代的回避习得减少有关。所得结果表明，妊娠期间暴露于镉的雌性大鼠成年后代大脑中铜和锌水平降低与中枢神经系统功能障碍之间存在关联。
