Srivastava D K, Pandey K C
Toxicol Lett. 1982 May;11(3-4):237-41. doi: 10.1016/0378-4274(82)90156-4.
In vitro exposure to 10(-6) and 10(-5) M copper caused a decline in the activity of acid and alkaline phosphatases in both liver and kidney of Ophiocephalus punctatus. While in vivo exposure to 5 and 7.5 mg/l copper resulted in the activation of alkaline phosphatase in the kidney, the activity of this enzyme in the liver was inhibited at the highest concentration. The acid phosphatase was inhibited in the liver and kidney on in vivo exposure to both concentrations. The varied responses of these enzymes to in vitro and in vivo exposure to copper indicate the involvement of different molecular processes.
在体外，将斑鳢的肝脏和肾脏暴露于10⁻⁶和10⁻⁵ M的铜中，会导致酸性和碱性磷酸酶的活性下降。而在体内，将其暴露于5和7.5 mg/l的铜中，会导致肾脏中碱性磷酸酶的活性激活，在最高浓度下肝脏中该酶的活性受到抑制。在体内暴露于这两种浓度下，肝脏和肾脏中的酸性磷酸酶均受到抑制。这些酶对体外和体内暴露于铜的不同反应表明涉及不同的分子过程。
