Jennings F W, Gray G D, Urquhart G M
Trans R Soc Trop Med Hyg. 1982;76(2):204-7. doi: 10.1016/0035-9203(82)90275-9.
Mice infected with T. brucei GVR 23/1 or T. brucei GVR 35/1 for 21 days were treated with the Erlangen diamidine 98/202 (6-amidino-2-[4' amidino-phenyl] thionaphthene-dilacate) at either 5 mg/kg or 35 mg/kg. At both these dose levels the parasites were initially cleared from the circulation although the infections eventually relapsed due to reinvasion from the central nervous system. If the 98/202 therapy is followed by treatment with 5-nitroimidazole only a small number of mice are permanently cured. Adverse reactions, especially at the 35 mg/kg dose level, were noted in one experiment. The Erlangen diamidine given to infected mice three days after infection was able to permanently cure both Trypanosoma brucei stabilates.
感染布氏锥虫GVR 23/1或布氏锥虫GVR 35/1达21天的小鼠，分别用埃尔朗根脒98/202（6-脒基-2-[4'-脒基苯基]硫茚二乳酸酯）以5毫克/千克或35毫克/千克的剂量进行治疗。在这两个剂量水平下，寄生虫最初都从循环系统中清除，但由于中枢神经系统的再次侵袭，感染最终复发。如果在98/202治疗后仅用5-硝基咪唑进行治疗，只有少数小鼠能被永久治愈。在一项实验中观察到了不良反应，尤其是在35毫克/千克剂量水平时。在感染后三天给感染小鼠施用埃尔朗根脒，能够永久治愈两种布氏锥虫稳定株。
