Mahler R J, Romanoff N E, Dunbar A, Granuci P, Jurgens C, Kirkpatrick J, Stickel K
West J Med. 1982 May;136(5):379-83.
A total of 1,009 persons were given a 100-gram glucose solution orally after a three-day regimen of a diet preparation and an overnight fast. Fasting and two-hour plasma glucose levels were determined for each subject and the results tabulated. Most of the persons tested were in the sixth, seventh or eighth decade of life with 43 persons between 80 and 89 years of age. The frequency of fasting plasma glucose determinations above 140 mg per dl varied from 3 percent to 7 percent between the sixth and ninth decades. Those persons with two-hour plasma glucose values above 200 mg per dl represented 8 percent of the 50 to 59 year old group and the percentages rose respectively to 12 percent, 16 percent and 21 percent in the 60 to 69, 70 to 79 and 80 to 89 year old groups. Finally, those who had fasting plasma glucose levels below 140 mg per dl and two-hour glucose values between 140 and 200 mg per dl were tabulated according to decade of life. This group varied from 9 percent to 15 percent between ages 20 and 59 and represented 20 percent to 22 percent of those in the seventh, eighth and ninth decades. In light of the known deterioration of glucose tolerance with aging, some stratification of blood glucose concentrations should be applied with age, but to what degree and what diagnostic criteria should be applied are still unclear.
在进行了为期三天的饮食准备和一夜禁食后，共有1009人口服了100克葡萄糖溶液。测定了每个受试者的空腹血糖和两小时血糖水平，并将结果制成表格。大多数受试人员年龄在六七十或八十岁，其中43人年龄在80至89岁之间。空腹血糖测定值高于每分升140毫克的频率在六七十岁到九十岁之间从3%到7%不等。两小时血糖值高于每分升200毫克的人员在50至59岁组中占8%，在60至69岁、70至79岁和80至89岁组中这一比例分别升至12%、16%和21%。最后，将空腹血糖水平低于每分升140毫克且两小时血糖值在140至200毫克之间的人员按年龄分组列表。该组在20至59岁之间占9%至15%，在七十、八十和九十岁组中占20%至22%。鉴于已知葡萄糖耐量会随着年龄增长而恶化，应根据年龄对血糖浓度进行一定分层，但分层程度以及应采用何种诊断标准仍不明确。
