Dorf A, Ballintine E J, Bennett P H, Miller M
Diabetes. 1976 Jul;25(7):554-60. doi: 10.2337/diab.25.7.554.
The occurrence of retinopathy and its relationship to diabetes in 1,640 Pima Indians age 15 and over has been determined. Eighteen per cent of those with two-hour postload plasma glucose levels of equal to or greater than 200 mg./dl. had some evidence of retinopathy. Of those with retinopathy and diabetes, 7 per cent were found to have proliferative or neovascular changes, the remainder having microaneurysms and/or exudates. The frequency of retinopathy increased from 3 per cent among newly diagnosed diabetics to 47 per cent among those with diabetes of 10 or more years duration. No relationship was found with sex, age at diagnosis of diabetes, or age at time of examination when duration of diabetes was taken into account. The occurrence of retinopathy was confined largely to those who fell into the second or hyperglycemic component of the frequency distribution of plasma glucose levels in the population, indicating the significance of the bimodal glucose tolerance frequency distribution.
已确定1640名15岁及以上皮马印第安人的视网膜病变发生率及其与糖尿病的关系。在那些两小时餐后血浆葡萄糖水平等于或高于200毫克/分升的人群中，18%有视网膜病变的某些迹象。在患有视网膜病变和糖尿病的人群中，7%被发现有增殖性或新生血管性改变，其余的有微动脉瘤和/或渗出物。视网膜病变的发生率从新诊断糖尿病患者中的3%增加到糖尿病病程达10年或更长时间患者中的47%。当考虑糖尿病病程时，未发现与性别、糖尿病诊断时的年龄或检查时的年龄有关。视网膜病变的发生主要局限于那些属于人群中血浆葡萄糖水平频率分布第二个或高血糖部分的人，这表明双峰糖耐量频率分布的重要性。
