Korkusko O V, Sarkisov K G, Frajfel'd V E
Z Alternsforsch. 1982 May-Jun;37(3):147-53.
The muscle blood flow was investigated at rest (MBFR) and after physical load under ischemia conditions (maximal muscle blood flow--MMBF) in 87 practically healthy persons (45 women and 42 men) aged 20--90. The state of muscle blood flow was evaluated by means of the clearance of 133xenon injected into M. tibialis anterior. The data obtained showed a decrease of MBFR and MMBF in older people as compared with younger subjects. In realization of this phenomenon a decrease in muscle capillarisation and a reduction in reactivity of microcirculatory link of vascular system plays an increasingly greater role with aging. The reduction in muscle blood flow forms a circulatory component of the age-associated hypoxia. This fact results in a decrease of muscle blood flow and limits the functional capacity of skeletal muscle under conditions of activity.
对87名年龄在20至90岁之间的健康人（45名女性和42名男性），在静息状态下（肌肉血流量——MBFR）以及缺血条件下（最大肌肉血流量——MMBF）进行体力负荷后，研究了肌肉血流量。通过注入胫前肌的133氙清除率来评估肌肉血流状态。所获数据表明，与年轻受试者相比，老年人的MBFR和MMBF有所下降。随着年龄增长，肌肉毛细血管化减少以及血管系统微循环环节反应性降低在这一现象的发生中起的作用越来越大。肌肉血流量减少形成了与年龄相关的缺氧的循环组成部分。这一事实导致肌肉血流量减少，并限制了骨骼肌在活动状态下的功能能力。
