Rogos R, Meisel B, Erler K
Z Gesamte Inn Med. 1982 May 1;37(9):271-5.
In altogether 31 patients with liver cirrhosis, fatty degeneration of the liver or a morphologically normal liver the free fatty acids, glycerin, ketone bodies and triglycerides were examined as parameters of the fat metabolism after nocturnal alimentary abstinence and under 2-hour glucose infusion. Parallel to this estimations of the immune-reactive insulin and of the blood glucose were performed. In liver cirrhoses increased levels of free fatty acids, low ketone body levels, the absent correlation between ketone bodies and immune-reactive insulin under basis conditions as well as the relatively smaller reduction of the TG-values in hyperinsulinaemia were to be established. They may be explained as an expression of restricted metabolic functions of the cirrhotic liver. On the other hand from the prompt decrease of free fatty acids and glycerin under glucose-induced hyperinsulinaemia was concluded to an unrestricted efficacy of the insulin in the fatty tissue in the sense of the furthering of lipogenesis and inhibition of the lipolysis.
在总共31例肝硬化、肝脏脂肪变性或肝脏形态正常的患者中，检测了夜间禁食和2小时葡萄糖输注后游离脂肪酸、甘油、酮体和甘油三酯作为脂肪代谢的参数。与此同时，还进行了免疫反应性胰岛素和血糖的测定。在肝硬化患者中，基础状态下游离脂肪酸水平升高、酮体水平降低、酮体与免疫反应性胰岛素之间缺乏相关性，以及高胰岛素血症时甘油三酯值相对较小的降低得以确立。这些可能被解释为肝硬化肝脏代谢功能受限的一种表现。另一方面，从葡萄糖诱导的高胰岛素血症下游离脂肪酸和甘油的迅速下降可以得出结论，胰岛素在促进脂肪生成和抑制脂肪分解方面对脂肪组织具有不受限制的作用。
