Hällgren R, Nôu E, Arrendal H, Hiesche K
Acta Med Scand. 1982;211(4):269-73. doi: 10.1111/j.0954-6820.1982.tb01943.x.
The serum concentrations of total IgE were significantly raised in smokers compared to those who had never smoked (p less than 0.005) among male patients with bronchial carcinoma, while no differences were found between smoking and non-smoking female bronchial carcinoma patients. The total IgE levels in male and female patients with non-malignant pulmonary diseases were not correlated to smoking habits. No significant differences in the IgE levels were observed between smoking males subgrouped according to the WHO histological types of bronchial carcinoma. Males with carcinoma who had stopped smoking more than 10 years ago had significantly reduced IgE levels compared to male cancer patients continuously smoking (p less than 0.01). These data, indicating that smoking is associated with elevated IgE levels in males with bronchial carcinoma, might suggest that smoking in certain, preferably male, individuals induces an impaired cellular immunity which is reflected by an enhanced IgE synthesis and a depressed resistance to carcinogens of tobacco smoke.
在男性支气管癌患者中，吸烟者的血清总IgE浓度显著高于从不吸烟者（p<0.005），而女性支气管癌患者中吸烟与不吸烟患者之间未发现差异。非恶性肺部疾病的男性和女性患者的总IgE水平与吸烟习惯无关。根据世界卫生组织支气管癌组织学类型对吸烟男性进行分组，各亚组的IgE水平未观察到显著差异。与持续吸烟的男性癌症患者相比，10多年前戒烟的男性癌症患者的IgE水平显著降低（p<0.01）。这些数据表明吸烟与男性支气管癌患者IgE水平升高有关，可能提示在某些个体（最好是男性）中吸烟会导致细胞免疫受损，这表现为IgE合成增加以及对烟草烟雾致癌物的抵抗力下降。
