Collins P, Oliver N M
Am J Med. 1982 Jul 20;73(1A):96-9. doi: 10.1016/0002-9343(82)90072-9.
Animal models of cutaneous herpes simplex and herpetic encephalitis were used to demonstrate the antiviral potential of acyclovir. Of the various topical formulations of acyclovir tested against herpes simplex in guinea pigs, 5 percent acyclovir in modified aqueous cream was the most effective. Propylene glycol was included in this preparation to increase the aqueous solubility of acyclovir. Acyclovir and vidarabine were found to be equally effective against herpetic encephalitis in mice when administered either orally or subcutaneously at 100 mg/kg.
皮肤单纯疱疹和疱疹性脑炎的动物模型被用于证明阿昔洛韦的抗病毒潜力。在豚鼠身上测试的各种阿昔洛韦局部制剂中，改良水乳膏中5%的阿昔洛韦最为有效。该制剂中包含丙二醇以增加阿昔洛韦的水溶性。当以100mg/kg的剂量口服或皮下给药时，发现阿昔洛韦和阿糖腺苷对小鼠疱疹性脑炎的疗效相同。
