Park N H, Pavan-Langston D, McLean S L, Lass J H
Arch Dermatol. 1980 Jun;116(6):672-5.
The chemotherapeutic efficacy of acyclovir was evaluated by observing the potential of topical acyclovir to reduce the severity of herpes viral lesions and to control the multiplication of this virus in the experimentally induced primary cutaneous infection of guinea pigs. Topical acyclovir showed a substantially high therapeutic efficacy when treatment was initiated after the development of clinically overt skin lesions. The therapeutic response was dose dependent and clearly evident even when the treatment was initiated on day 2 after inoculation. Our results indicate that topical acyclovir treatment improved the cutaneous herpes simplex virus type 1 (HSV-1) infectious process by inhibiting multiplication of HSV-1 in the skin of guinea pigs.
通过观察局部使用阿昔洛韦减轻疱疹病毒损伤严重程度以及控制该病毒在豚鼠实验性原发性皮肤感染中的增殖能力，来评估阿昔洛韦的化疗效果。当在临床明显的皮肤损伤出现后开始治疗时，局部使用阿昔洛韦显示出相当高的治疗效果。治疗反应呈剂量依赖性，即使在接种后第2天开始治疗也明显可见。我们的结果表明，局部使用阿昔洛韦治疗可通过抑制单纯疱疹病毒1型（HSV-1）在豚鼠皮肤中的增殖来改善皮肤感染过程。
