Djursing H, Nyholm H C, Hagen C, Carstensen L, Pedersen L M
Am J Obstet Gynecol. 1982 Aug 15;143(8):876-82. doi: 10.1016/0002-9378(82)90466-5.
Clinical characteristics and basal hormonal parameters related to ovulatory function were investigated in 22 diabetic patients with anovulation (group 1) and in nine normally menstruating diabetic patients (group 2) and 45 nondiabetic patients with anovulation (group 3). No significant differences according to control of the diabetes were demonstrated within the two diabetic groups. Groups 1 and 3 did not differ according to classification of anovulation. Group 1 had significantly (P less than 0.01) lower levels of prolactin (PRL), 17 beta-estradiol (E2), thyrotropin (TSH), 3,3',5-triiodothyronine (T3), and thyroxine (T4) than those of group 3, and significantly (P less than 0.01) lower levels of E2 and TSH than those of group 2. The urinary excretion of cortisol was significantly higher in group 1 than in group 2 (P less than 0.05) and group 3 (P less than 0.01). These data suggest a derangement in pituitary-gonadal feedback mechanisms or a depression of pituitary function in anovulatory diabetic patients, and we hypothesize that an increased central/peripheral dopamine and/or cortisol activity in these patients may to some extent influence the hypothalamic-pituitary axis.
对22例无排卵糖尿病患者（第1组）、9例月经正常的糖尿病患者（第2组）以及45例无排卵非糖尿病患者（第3组）的临床特征和与排卵功能相关的基础激素参数进行了研究。在两个糖尿病组中，未发现根据糖尿病控制情况存在显著差异。第1组和第3组在无排卵分类方面无差异。第1组的催乳素（PRL）、17β-雌二醇（E2）、促甲状腺激素（TSH）、三碘甲状腺原氨酸（T3）和甲状腺素（T4）水平显著低于第3组（P<0.01），且E2和TSH水平显著低于第2组（P<0.01）。第1组的皮质醇尿排泄量显著高于第2组（P<0.05）和第3组（P<0.01）。这些数据提示无排卵糖尿病患者存在垂体-性腺反馈机制紊乱或垂体功能减退，我们推测这些患者中枢/外周多巴胺和/或皮质醇活性增加可能在一定程度上影响下丘脑-垂体轴。
