Hunter G W, Yokogawa M, Akusawa M, Sano M, Araki K, Kobayashi M
Am J Trop Med Hyg. 1982 Jul;31(4):760-70. doi: 10.4269/ajtmh.1982.31.760.
A pilot experiment using NaPCP as a molluscicide to control schistosomiasis japonica was initiated in 1950--51 in Nagatoishi-cho, Kurume, Japan, where 1,050 persons lived behind dikes built to prevent flooding from the Chikugo River. They farmed 60 ha of rice, and 72.9% of them were infected with schistosomiasis. At the end of 2 years, 99.5% of the snails (Oncomelania h. nosophora) were controlled and new cases dropped from 30--35 per year to 5 and 0 at the end of the 1st and 2nd year, respectively. Mollusciciding was continued by Japanese, and paddy irrigation ditches were lined with concrete by 1958. Land reclamation, involving conversion of cultivated land in the river bottom to a golf course, resulted in virtual elimination of infected snails from this area and, when found, snails were uninfected. Using immunologic tests (intradermal, complement fixation, and circumoval precipitation) plus multiple stool examinations in 1972 and 1978, it was possible to demonstrate a marked decrease in cases of schistosomiasis in children 15 years of age or younger. These results were significantly different (P less than 0.001) from those found in similar tests run in 1940 and 1966. By 1978 all children in the Nagatoishi area of Kurume, Japan, were negative for Schistosoma japonicum infection.
1950 - 1951年，在日本久留米市长石町开展了一项试点实验，使用五氯酚钠作为杀螺剂来控制日本血吸虫病。该地有1050人居住在为防止筑后川洪水泛滥而修建的堤坝后面。他们耕种60公顷稻田，其中72.9%的人感染了血吸虫病。两年后，99.5%的钉螺（日本钉螺指名亚种）被控制住，新发病例从每年30 - 35例分别降至第1年末的5例和第2年末的0例。日本人继续进行灭螺工作，到1958年稻田灌溉沟渠都铺上了混凝土。土地开垦，即将河底耕地改造成高尔夫球场，使得该地区几乎消除了受感染的钉螺，即便发现钉螺，其也未被感染。1972年和1978年，通过免疫检测（皮内试验、补体结合试验和环卵沉淀试验）以及多次粪便检查，发现15岁及以下儿童的血吸虫病病例显著减少。这些结果与1940年和1966年进行的类似检测结果有显著差异（P小于0.001）。到1978年，日本久留米市长石地区的所有儿童日本血吸虫感染检测均呈阴性。
