Meyerhoff W L, Giebink G S, Shea D A, Le C T
Am J Otolaryngol. 1982 May-Jun;3(3):189-95. doi: 10.1016/s0196-0709(82)80053-7.
Intubation of the tympanic membrane as a treatment for acute otitis media is extremely controversial. This study was designed to determine the effect of tympanic membrane intubation in an experimental model for acute purulent otitis media. The right tympanic membrane of the chinchilla was intubated with Paparella Type I tympanostomy tubes. This procedure was followed in seven days by nasopharyngeal inoculation of Streptococcus pneumoniae and in an additional three days by nasopharyngeal inoculation of influenza A virus. Nasopharyngeal inoculation with these microorganisms results in acute purulent otitis media in 70 per cent of animals. The presence of the tympanostomy tubes did not reduce the incidence of clinical otitis media, nor did it reduce the pathologic changes within the middle ear space. The tympanostomy tubes did, however, significantly reduce the incidence and severity of pathologic changes in the subepithelial space of the middle ear mucosa.
鼓膜置管作为急性中耳炎的一种治疗方法极具争议性。本研究旨在确定在急性化脓性中耳炎实验模型中鼓膜置管的效果。用帕帕雷拉I型鼓膜造口管对龙猫的右鼓膜进行置管。此操作7天后经鼻咽接种肺炎链球菌，再过3天经鼻咽接种甲型流感病毒。用这些微生物进行鼻咽接种会使70%的动物发生急性化脓性中耳炎。鼓膜造口管的存在并未降低临床中耳炎的发生率，也未减轻中耳腔内的病理变化。然而，鼓膜造口管确实显著降低了中耳黏膜上皮下间隙病理变化的发生率和严重程度。
