Ikeda K, Sakagami M, Morizono T, Juhn S K
Department of Otolaryngology, University of Minnesota Medical School, Minneapolis.
Arch Otolaryngol Head Neck Surg. 1990 Jan;116(1):57-60. doi: 10.1001/archotol.1990.01870010061018.
The effect of pneumococcal otitis media on the permeability of the round window membrane was evaluated using tetraethylammonium ions as a tracer. Round window membrane permeability is reduced significantly at resolved stages of purulent otitis media. In contrast, measurements of round window membrane permeability indicate that acute purulent otitis media has a tendency to facilitate such permeability. Moreover, histologic observations of the round window membrane following bacterial inoculation further support the evidence of functional changes in round window membrane permeability. These findings indicate that the round window membrane in resolved stages of purulent otitis media plays a protective role in preventing the penetration of harmful substances into the inner ear.
使用四乙铵离子作为示踪剂，评估了肺炎球菌性中耳炎对圆窗膜通透性的影响。在化脓性中耳炎的消散期，圆窗膜通透性显著降低。相比之下，圆窗膜通透性的测量表明，急性化脓性中耳炎有促进这种通透性的趋势。此外，细菌接种后对圆窗膜的组织学观察进一步支持了圆窗膜通透性功能变化的证据。这些发现表明，化脓性中耳炎消散期的圆窗膜在防止有害物质侵入内耳方面起到了保护作用。
