Wrobel J, Koh T C, Saunders J M
Anaesth Intensive Care. 1982 May;10(2):116-9. doi: 10.1177/0310057X8201000204.
In a double-blind study, 107 patients undergoing elective and emergency surgical procedures were given 15 ml of either sodium citrate 0.3 M or placebo 10 minutes before induction of anaesthesia. Gastric contents were sampled immediately after induction and the pH was measured. The mean pH of the Gastric contents of patients given sodium citrate was 5.67, whereas for those given the placebo it was 3.21 (p less than 0.001). Of patients given sodium citrate 92% had a gastric pH above 3.0 compared with only 37% in the placebo group (p less than 0.001). At the end of surgery gastric contents were emptied as completely as possible and the volume and pH measured. There was no significant difference in the mean volume of gastric contents in the two groups. In neither group was the mean pH at the end of surgery significantly different from that after induction.
在一项双盲研究中，107例接受择期和急诊外科手术的患者在麻醉诱导前10分钟给予15毫升0.3M柠檬酸钠或安慰剂。诱导后立即采集胃内容物样本并测量pH值。给予柠檬酸钠的患者胃内容物的平均pH值为5.67，而给予安慰剂的患者为3.21（p<0.001）。给予柠檬酸钠的患者中92%的胃pH值高于3.0，而安慰剂组仅为37%（p<0.001）。手术结束时，尽可能排空胃内容物并测量其体积和pH值。两组胃内容物的平均体积无显著差异。两组在手术结束时的平均pH值与诱导后均无显著差异。
