[胰高血糖素与糖尿病发病机制（作者译）]
[Pancreatic glucagon and the pathogenesis of diabetes mellitus (author's transl)].
作者信息
Dammann H G, Kühnau J, Drost H, Schreiber H W
出版信息
Dtsch Med Wochenschr. 1978 Nov 24;103(47):1870-2. doi: 10.1055/s-0028-1129359.
PMID:710311
Abstract
Eleven patients who had had total pancreatic resection had hyperglycaemia (16.8 +/- 7.7 mmol/1 corresponding to 3.02 +/- 1.38 g/l) after fasting for 14 or 36 hours. After arginine stimulation there was no evidence for pancreatic glucagon. These findings indicate that (1) in man there are no sites of pancreatic glucagon production outside of the (resected) pancreas; (2) marked hyperglycaemia may occur without glucagon.
摘要
11例接受全胰切除术的患者在禁食14或36小时后出现高血糖（16.8±7.7 mmol/L，相当于3.02±1.38 g/L）。精氨酸刺激后未发现胰高血糖素分泌证据。这些发现表明：（1）在人类中，（切除后的）胰腺外不存在胰高血糖素产生部位；（2）无胰高血糖素时也可能出现明显的高血糖。
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