Wagenknecht L V, Becker H, Langendorff H M, Schäfer H
Andrologia. 1982 Mar-Apr;14(2):182-9. doi: 10.1111/j.1439-0272.1982.tb03122.x.
In order to examine the effect of contrast mediums of different concentration and composition upon the vas, experiments in 90 rats were done. In comparison to three control groups of 10 animals each (surgery only, vas ligation only, saline injection) six contrast mediums caused a varying degree of damage to the vas deferens. The latter included irritation of the epithelium, inflammation, cellular infiltration, fibrosis of the wall, septum-formation and fenestration within the vas and actual obliteration. According to these experiments only hydrophilic contrast mediums of low concentration should be used in humans for vasography.
为研究不同浓度和成分的造影剂对输精管的影响，对90只大鼠进行了实验。与三个每组10只动物的对照组（仅手术、仅输精管结扎、注射生理盐水）相比，六种造影剂对输精管造成了不同程度的损害。损害包括上皮刺激、炎症、细胞浸润、管壁纤维化、输精管内隔膜形成和开窗以及实际闭塞。根据这些实验，人类输精管造影仅应使用低浓度的亲水性造影剂。
