Bertram R A, Carson C C, Szpak C
J Urol. 1985 Jun;133(6):1087-9. doi: 10.1016/s0022-5347(17)49385-2.
Vasography is a common diagnostic procedure utilized in evaluating the male genital tract for causes of azoospermia, for evaluation of persistent perineal pain and seminal vesiculitis, and recently used in the staging of prostate cancer. In order to evaluate the effects of injectable agents on the healthy vas deferens, 7 groups of 10 rats had the left vas deferens injected by vasopuncture with saline, 4 contrast agents, doxycycline and absolute alcohol. The animals were sacrificed 8 weeks later, and were examined for patency of the vas and inflammatory response. Results revealed that vasopuncture did not produce obstruction. Vasography with water-soluble contrast media does entail a low risk of inflammation in the rat, but produces no obstruction. Intra-vas injection of doxycycline, injected by some for treatment of chronic seminal vesiculitis and perineal pain, is not deleterious in the rat model.
输精管造影术是一种常见的诊断程序，用于评估男性生殖道无精子症的病因、持续性会阴疼痛和精囊炎，最近也用于前列腺癌的分期。为了评估注射剂对健康输精管的影响，将7组每组10只大鼠通过输精管穿刺向左侧输精管注射生理盐水、4种造影剂、强力霉素和无水乙醇。8周后处死动物，检查输精管通畅情况和炎症反应。结果显示，输精管穿刺未造成阻塞。水溶性造影剂进行输精管造影在大鼠中确实存在低炎症风险，但不会造成阻塞。一些人用于治疗慢性精囊炎和会阴疼痛而进行的输精管内注射强力霉素，在大鼠模型中并无危害。
