Pittman D L, Glab W N, Mansfield L E
Ann Allergy. 1982 Aug;49(2):104-6.
Immature guinea pigs underwent eight weeks of methacholine-induced wheezing on a daily basis. At the end of the study the treated guinea pigs showed less of a weight gain than control animals. Relative dry tracheal weight was greater in the methacholine group than in controls. However, there were no differences noted on histologic examination of the lungs between the treated and control animals. Although experimentally induced amounts of bronchoconstriction may not be extrapolated to the same degree as seen in asthma, these findings suggest that repeated bronchoconstriction alone is not the cause of the smooth muscle hypertrophy and hyperplasia found in asthma.
未成熟豚鼠每天接受八周的乙酰甲胆碱诱导性喘息。在研究结束时，经治疗的豚鼠体重增加比对照动物少。乙酰甲胆碱组的气管相对干重高于对照组。然而，经治疗的动物与对照动物在肺组织学检查上未发现差异。尽管实验诱导的支气管收缩程度可能无法完全推断为与哮喘中所见相同，但这些发现表明，单纯反复的支气管收缩并非哮喘中平滑肌肥大和增生的原因。
