Anolik R, Kolski G B, Schaible D H, Ratner J
Ann Allergy. 1982 Aug;49(2):109-11.
Transient alteration of theophylline half-life resulting in theophylline neurotoxicity is reported in a nine-year-old child. The alteration in theophylline elimination half-life was associated with Herpes simplex gingivostomatitis. This association has not previously been demonstrated. The report is contrasted with a study of theophylline clearance variability in children.
据报道，一名9岁儿童出现了茶碱半衰期的短暂改变，导致茶碱神经毒性。茶碱消除半衰期的改变与单纯疱疹性龈口炎有关。这种关联以前尚未得到证实。该报告与一项关于儿童茶碱清除率变异性的研究形成对比。
