Pellegrin M J, Astoin M
Arch Int Physiol Biochim. 1976 Apr;84(2):285-92. doi: 10.3109/13813457609073979.
Distribution of radioactivity in different tissues has been studied by liquid scintillation counting 60 sec after administration of [3H] PGE2 and [3H] PGA2 in the rat. In addition, renal autoradiographs were prepared 15 sec and 60 sec after tritiated PG administration. In some experiments, [3H] PGE2 was accompanied by a large dose of PGE2 (isotopic dilution). 60 sec after [3H] PGE2 administration, radioactivity concentrates principally in the kidney, followed by the liver and the lung. Within the kidney, radioactivity concentrated predominantly in the cortex. Isotopic dilution diminished radioactivity due to [3H] PGE2 in all regions of the kidney. Renal autoradiographs 15 sec after [3H] PGE2 administration showed cortical radioactivity to be higher in glomeruli than in tubules. After [3H] PGA2 radioactivity also concentrates in the kidney, liver and lung but to a lesser extent than after [3H] PGE2 and no glomerular concentration of radioactivity was found.
在大鼠体内给予[³H]前列地尔（PGE₂）和[³H]前列环酸（PGA₂）60秒后，通过液体闪烁计数法研究了不同组织中放射性的分布情况。此外，在给予氚标记的前列腺素15秒和60秒后制备了肾脏放射自显影片。在一些实验中，[³H]前列地尔伴随着大剂量的前列地尔（同位素稀释）。给予[³H]前列地尔60秒后，放射性主要集中在肾脏，其次是肝脏和肺。在肾脏内部，放射性主要集中在皮质。同位素稀释降低了肾脏所有区域中[³H]前列地尔所致的放射性。给予[³H]前列地尔15秒后的肾脏放射自显影片显示，肾小球中的皮质放射性高于肾小管。给予[³H]前列环酸后，放射性也集中在肾脏、肝脏和肺中，但程度低于给予[³H]前列地尔之后，且未发现放射性在肾小球中的聚集。
