Borgman R F, Lightsey S F
Am J Vet Res. 1982 Aug;43(8):1432-5.
Rabbits were fed a purified ration known to result in cholelithiasis and alterations in lipid metabolism. During a 12-week experimental period, either synthesized hard water (500 mg of Ca/L and 100 mg of Mg/L) or deionized distilled water were available as drinking water, and half of each of these groups of rabbits were also given 5 mg of Cd/L of water. Hair samples taken at the beginning and end of the experiment revealed an increase in the Ca concentration in rabbits given hard water, but no increase in Cd in rabbits given this element in the water. Cadmium in the drinking water resulted in accumulations of this element in liver and kidneys, and water hardness did not influence the amount of accumulation. Liver cholesterol concentrations and the severity of cholelithiasis were less in rabbits given Cd. The hard water administration resulted in lower liver cholesterol concentrations and less cholelithiasis. These results indicate that hard water does not reduce cardiovascular disease frequency by lessening Cd accumulation, but may affect cholesterol metabolism.
给兔子喂食一种已知会导致胆结石和脂质代谢改变的纯化日粮。在为期12周的实验期内，合成硬水（钙500毫克/升和镁100毫克/升）或去离子蒸馏水可作为饮用水，每组兔子中有一半还被给予5毫克/升的镉水溶液。在实验开始和结束时采集的毛发样本显示，饮用硬水的兔子体内钙浓度增加，但饮用含镉水的兔子体内镉浓度未增加。饮用水中的镉导致该元素在肝脏和肾脏中蓄积，而水的硬度并不影响镉的蓄积量。给予镉的兔子肝脏胆固醇浓度和胆结石严重程度较低。给予硬水导致肝脏胆固醇浓度较低且胆结石较少。这些结果表明，硬水不会通过减少镉的蓄积来降低心血管疾病的发生率，但可能会影响胆固醇代谢。
