Krumholz A, Weiss H D, Jiji V H, Bakal D, Kirsh M B
Ann Neurol. 1982 May;11(5):529-32. doi: 10.1002/ana.410110514.
Solitary neoplastic proliferation of plasma cells (plasmacytoma) rarely occurs in the central nervous system. The longest follow-Up in nine previously reported patients was 5 years. We have followed two patients with solitary intracranial plasmacytoma for 8 and 13 years, respectively. At the time of biopsy diagnosis, neither showed involvement of the adjacent calvarium or evidence of a systemic plasma cell dyscrasia. The first patient underwent partial excision of a mass in the right occipital lobe that showed no gross or microscopic involvement of the dura. The second patient had partial resection of a mass arising from dura and invading the left temporal lobe. Postoperative irradiation was given to both patients. No clinical or radiological sign of recurrent brain tumor has developed in either patient during the extended follow-up period. Neither patient has had laboratory or clinical evidence of a systemic plasma cell dyscrasia. Solitary intracranial plasmacytoma may be a "curable" brain tumor.
浆细胞的孤立性肿瘤性增殖（浆细胞瘤）在中枢神经系统中很少见。先前报道的9例患者的最长随访时间为5年。我们分别对2例孤立性颅内浆细胞瘤患者进行了8年和13年的随访。在活检诊断时，两者均未显示相邻颅骨受累或全身性浆细胞发育异常的证据。第一例患者接受了右枕叶肿块的部分切除，该肿块在大体或显微镜下均未显示硬脑膜受累。第二例患者对起源于硬脑膜并侵犯左颞叶的肿块进行了部分切除。两名患者均接受了术后放疗。在延长的随访期内，两名患者均未出现复发性脑肿瘤的临床或放射学征象。两名患者均无全身性浆细胞发育异常的实验室或临床证据。孤立性颅内浆细胞瘤可能是一种“可治愈的”脑肿瘤。
