Burkhardt D, Schipper H I, Kaboth U, Felgenhauer K
Department of Neurology, University of Goettingen, Germany.
J Neurol Neurosurg Psychiatry. 1992 Jul;55(7):623-5. doi: 10.1136/jnnp.55.7.623.
The first case of a primary and solitary IgA (lambda) producing tumour (possibly a non-Hodgkin's lymphoma) in the CNS is reported. Clinical and neuroimaging findings are described. Early diagnosis without brain biopsy and successful therapy were possible by CSF and serum immunoglobulin analysis which proved local paraprotein production restricted to the CNS.
报告了首例中枢神经系统原发性孤立性产生IgA(λ)的肿瘤(可能是非霍奇金淋巴瘤)。描述了临床和神经影像学检查结果。通过脑脊液和血清免疫球蛋白分析实现了无需脑活检的早期诊断和成功治疗,该分析证明局部副蛋白产生仅限于中枢神经系统。