Beauvais P
Arch Fr Pediatr. 1982 Mar;39(3):141-4.
On the occasion of 34 spleen scintigrams performed in children with sickle cell anemia, the frequency and precocity of the "functional asplenia" is emphasized and its relationship with the infectious history of such children is discussed. The anti-bacterial role of the spleen and the responsibility, at least partial, or asplenia in the susceptibility of patients with sickle cell anemia to infections, especially pneumococcal ones, are reviewed. The pathophysiologic mechanism of functional asplenia is then discussed. The author concludes that asplenia has no predictive value in selecting children "at risk" for infection and stresses the necessity of a systematic prevention by penicillin therapy and antipneumococcal vaccination in such patients before 4 years of age.
在对镰状细胞贫血患儿进行的34次脾脏闪烁扫描检查中，强调了“功能性无脾”的发生率和早熟情况，并讨论了其与这些患儿感染史的关系。回顾了脾脏的抗菌作用以及至少部分无脾在镰状细胞贫血患者易感染性（尤其是肺炎球菌感染）中的责任。接着讨论了功能性无脾的病理生理机制。作者得出结论，无脾在选择感染“高危”儿童方面没有预测价值，并强调在这些患者4岁之前通过青霉素治疗和肺炎球菌疫苗接种进行系统预防的必要性。
