长-伊文斯大鼠中11-脱氧皮质酮（DOC）诱导的高血压的发生情况。

The occurrence of 11-deoxycorticosterone (DOC)-induced hypertension in the Long-Evans rat.

作者信息

Brownie A C, Gallant S, Nickerson P A, Joseph L M

出版信息

Endocr Res Commun. 1978;5(1):71-80. doi: 10.1080/07435807809073637.

Abstract

The sensitivity of two strains of rat to the hypertensinogenic action of DOC was studied. Hypertensive cardiovascular disease was evident within 3 weeks of implantation of DOC pellets in sensitized female rats of the Sprague-Dawley and Long-Evans strains. Cardiac and renal hypertrophy due to DOC treatment was evident in both strains of rat. The DOC treatment also resulted in a significant decrease in absolute adrenal weight. These results, which indicate that Long-Evans rats are not resistant to DOC-induced hypertension, contrast with previous reports by others. An explanation of the discrepancy may be the use of free DOC rather than DOC acetate in the present study.

摘要

研究了两株大鼠对脱氧皮质酮（DOC）致高血压作用的敏感性。在将DOC丸植入斯普拉格-道利（Sprague-Dawley）和长-伊文斯（Long-Evans）品系的致敏雌性大鼠体内3周内，高血压性心血管疾病就很明显。DOC处理导致的心脏和肾脏肥大在这两个品系的大鼠中都很明显。DOC处理还导致肾上腺绝对重量显著降低。这些结果表明长-伊文斯大鼠对DOC诱导的高血压并不具有抗性，这与其他人之前的报道形成了对比。差异的一个解释可能是本研究中使用的是游离DOC而非醋酸脱氧皮质酮。