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L-2-Amino-4-methoxy-cis-but-3-enoic acid, a potent inhibitor of the enzymatic synthesis of S-adenosylmethionine.

作者信息

Sufrin J R, Lombardini J B, Keith D D

出版信息

Biochem Biophys Res Commun. 1982 May 31;106(2):251-5. doi: 10.1016/0006-291x(82)91102-0.

DOI:10.1016/0006-291x(82)91102-0
PMID:7103990
Abstract
摘要

相似文献

1
L-2-Amino-4-methoxy-cis-but-3-enoic acid, a potent inhibitor of the enzymatic synthesis of S-adenosylmethionine.L-2-氨基-4-甲氧基-顺式-丁-3-烯酸，一种S-腺苷甲硫氨酸酶促合成的强效抑制剂。
Biochem Biophys Res Commun. 1982 May 31;106(2):251-5. doi: 10.1016/0006-291x(82)91102-0.
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Isozyme-specific enzyme inhibitors. 12. C- and N-methylmethionines as substrates and inhibitors of methionine adenosyltransferases of normal and hepatoma rat tissues.
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Selenite toxicity, depletion of liver S-adenosylmethionine, and inactivation of methionine adenosyltransferase.
Arch Biochem Biophys. 1977 Feb;179(1):136-40. doi: 10.1016/0003-9861(77)90096-0.
5
Differential kinetic properties of L-2-amino-4-methylthio-cis-but-3-enoic acid, a methionine analog inhibitor of S-adenosylmethionine synthetase.L-2-氨基-4-甲硫基-顺式-丁-3-烯酸（一种S-腺苷甲硫氨酸合成酶的甲硫氨酸类似物抑制剂）的差异动力学性质。
Biochim Biophys Acta. 1993 Sep 3;1202(1):87-91. doi: 10.1016/0167-4838(93)90067-2.
6
Isozyme-specific enzyme inhibitors. 10. Adenosine 5'-triphosphate derivatives as substrates or inhibitors of methionine adenosyltransferases of rat normal and hepatoma tissues.同工酶特异性酶抑制剂。10. 5'-三磷酸腺苷衍生物作为大鼠正常组织和肝癌组织中甲硫氨酸腺苷转移酶的底物或抑制剂
J Med Chem. 1986 Mar;29(3):318-22. doi: 10.1021/jm00153a003.
7
Correlation of isozyme patterns of S-adenosylmethionine synthetase with fetal stages and pathological states of the liver.S-腺苷甲硫氨酸合成酶同工酶模式与胎儿发育阶段及肝脏病理状态的相关性
Cancer Res. 1979 Jan;39(1):162-9.
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Growth inhibition by methionine analog inhibitors of S-adenosylmethionine biosynthesis in the absence of polyamine depletion.在不存在多胺耗竭的情况下，S-腺苷甲硫氨酸生物合成的甲硫氨酸类似物抑制剂对生长的抑制作用。
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Inhibitors of ATP: L-methionine S-adenosyltransferase--L-methionine analogues.
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Isozyme-specific enzyme inhibitors. 13. S-[5'(R)-[(N-triphosphoamino)methyl]adenosyl]-L-homocysteine, a potent inhibitor of rat methionine adenosyltransferases.
J Med Chem. 1987 May;30(5):888-94. doi: 10.1021/jm00388a024.

引用本文的文献

1
In Vitro Biosynthesis of the Nonproteinogenic Amino Acid Methoxyvinylglycine.体外生物合成非蛋白氨基酸甲氧基乙烯基甘氨酸。
Angew Chem Int Ed Engl. 2018 Jun 4;57(23):6780-6785. doi: 10.1002/anie.201713419. Epub 2018 May 8.
2
Discovery of novel types of inhibitors of S-adenosylmethionine synthesis by virtual screening.通过虚拟筛选发现新型S-腺苷甲硫氨酸合成抑制剂
J Med Chem. 2009 Oct 8;52(19):5967-73. doi: 10.1021/jm9006142.
3
Phosphoanalogues of amino acids involved in methionine metabolism as a new source of antiviral compounds.
作为抗病毒化合物新来源的蛋氨酸代谢中氨基酸的磷酸类似物。
Dokl Biochem Biophys. 2009 Mar-Apr;425:84-6. doi: 10.1134/s1607672909020070.
4
Molecular aspects of the in vivo and in vitro effects of ethionine, an analog of methionine.蛋氨酸类似物乙硫氨酸在体内和体外作用的分子层面研究
Microbiol Rev. 1982 Sep;46(3):281-95. doi: 10.1128/mr.46.3.281-295.1982.
5
Selective inhibition of alanine aminotransferase and aspartate aminotransferase in rat hepatocytes.大鼠肝细胞中丙氨酸氨基转移酶和天冬氨酸氨基转移酶的选择性抑制
Biochem J. 1984 Jun 15;220(3):707-16. doi: 10.1042/bj2200707.
6
Relative effects of S-adenosylmethionine depletion on nucleic acid methylation and polyamine biosynthesis.S-腺苷甲硫氨酸耗竭对核酸甲基化和多胺生物合成的相对影响。
Biochem J. 1987 Oct 15;247(2):259-65. doi: 10.1042/bj2470259.
7
Modulation of polyamine-biosynthetic activity by S-adenosylmethionine depletion.通过S-腺苷甲硫氨酸耗竭对多胺生物合成活性的调节。
Biochem J. 1988 Jan 15;249(2):581-6. doi: 10.1042/bj2490581.